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Pharmacological evaluation of Shokyo and Kankyo (1)
Kazunori Hashimoto1, Yoshio Kase, Pin Murata
1Kampo & Pharmacognosy Laboratory, Tsumura & Co., Inashiki-gun Ibaraki, Japan. hashimoto_kazunori@mail.tsumura.co.jp
Abstract:
Zingiberis Rhizoma (Shokyo, [Japanese characters: see text]) showed significant ameliorative effect on the BaCl2-induced delay of gastric emptying in rat. Bioassay-guided fractionation of the aqueous extract of Shokyo resulted in isolation of 6-gingesulfonic acid (1) and shogasulfonic acid A (3). These compounds significantly improved the delay of gastric emptying on both BaCl2-induced and N(G)-nitro-L-arginine (L-NNA)-induced model in rat. Zingiberis Siccatum Rhizoma (Kankyo, [Japanese characters: see text]) had significant efficacy against castor oil-induced diarrhea. In addition, Kankyo showed the activity increasing intestinal blood flow in normal rat.