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Updated: Jul 23, 2026

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Three-dimensional prenatal diagnosis of frontonasal malformation and unilateral cleft lip/palate
T D Shipp1, J B Mulliken, B Bromley
1Department of Obstetrics and Gynecology, Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. tshipp@partners.org
Abstract:
Frontonasal malformation includes a spectrum of anomalies involving the eyes, nose, lips, forehead and brain. We present a case in which a fetal labial cleft was initially identified using traditional two-dimensional sonography. Three-dimensional sonography with multiplanar reconstruction and surface-rendering were essential to establish the diagnosis of frontonasal malformation with severe nasal hypoplasia and unilateral complete cleft lip/palate.
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