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Lipid rafts and assembly of enveloped viruses
1Department of Biosciences at Novum, Karolinska Institutet, S-141 57 Huddinge, Sweden. maarit.suomalainen@cbt.ki.se
Traffic (Copenhagen, Denmark)
|September 17, 2002
Abstract:
The plasma membrane, late secretory pathway and endosomal compartments contain detergent-insoluble raft microdomains that are enriched in sphingolipids and cholesterol. Rafts are currently an intensively studied topic of cell biology, and raft involvement has been implicated in numerous cellular processes. A number of recent reports have localized structural proteins of several enveloped viruses to rafts, thus raising the possibility that rafts also play a role in the assembly and budding of viruses, but what exactly that role might be is still unknown.