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Updated: Sep 29, 2026
Studying Chronic Exposure of Mice to Ultraviolet B Radiation
Published on: August 19, 2025
Protective effect of polypeptide from Chlamys farreri on hairless mice damaged by ultraviolet A
Chun-Bo Wang1, Ru-Yong Yao, Zhan-Tao Liu
1Medical College Qingdao University, Qingdao 266021, China.
Aim:
To study the protective effect of the polypeptide isolated from Chlamys farreri (PCF) on hairless mice skin damaged by ultraviolet A.
Methods:
Enzymes and malondialdehyde (MDA) were determined by biochemical methods; the expressions of Bcl-2 protein and NOS protein were examined by immunohistochemical technique. The ultra-structure of the skin was observed through electronic microscope.
Results:
PCF could enhance the activities of glutathione peroxidase (GSH-px), superoxide dismutase (SOD), and total anti-oxidative capacity (T-AOC). Also PCF could reduce the amount of MDA, increase the expression of Bcl-2 protein, and inhibit the expression of NOS protein. The ultra-structure of epidermis and fibroblasts remained normal in 20 % PCF groups; there were vacuoles in smooth endoplasm reticulum in epidermis of mice and the number of rough endoplasm reticulum in fibroblasts was decreased in model group.
Conclusion:
PCF had the protective effects on hairless mice skin damaged by ultraviolet A via its anti-oxidative mechanisms.
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