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Desmosomal cadherins
David R Garrod1, Anita J Merritt, Zhuxiang Nie
1School of Biological Sciences, University of Manchester, UK. david.garrod@man.ac.uk
Current Opinion in Cell Biology
|September 17, 2002
Abstract:
New evidence from blocking desmosomal adhesion with anti-adhesion peptides reveals a role for desmosomes in cell positioning in morphogenesis. Desmosomal adhesion is necessary for the stability of adherens junctions in epithelial cell sheets. Knockout and mis-expression of desmosomal cadherins in mice suggests that they may function directly or indirectly in regulating epidermal differentiation. Protein kinase C signalling and tyrosine phosphorylation appear to regulate desmosomal adhesion. There are new insights into the role of desmosomal cadherins in autoimmune, infectious and genetic disease.