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Related Experiment Videos

Desmosomal cadherins.

David R Garrod1, Anita J Merritt, Zhuxiang Nie

  • 1School of Biological Sciences, University of Manchester, UK. david.garrod@man.ac.uk

Current Opinion in Cell Biology
|September 17, 2002
PubMed
Summary
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New research shows desmosomes are crucial for cell positioning during development. Blocking desmosomal adhesion impacts epithelial cell sheets and epidermal differentiation, offering insights into diseases.

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Molecular Biology

Background:

  • Desmosomes are critical cell-cell adhesion structures in epithelial tissues.
  • Their role in morphogenesis and epidermal differentiation is not fully understood.
  • Regulation of desmosomal adhesion by signaling pathways is an active area of research.

Purpose of the Study:

  • To investigate the role of desmosomes in cell positioning during morphogenesis.
  • To explore the functional significance of desmosomal cadherins in epidermal differentiation.
  • To elucidate the regulatory mechanisms of desmosomal adhesion.

Main Methods:

  • Utilizing anti-adhesion peptides to block desmosomal adhesion.
  • Employing knockout and mis-expression models in mice.

Related Experiment Videos

  • Analyzing Protein Kinase C signaling and tyrosine phosphorylation.

    • Main Results:

    • Blocking desmosomal adhesion revealed its role in cell positioning during morphogenesis.
    • Desmosomal adhesion is essential for the stability of adherens junctions in epithelial cell sheets.
    • Evidence suggests desmosomal cadherins regulate epidermal differentiation.
    • Protein kinase C signaling and tyrosine phosphorylation are implicated in regulating desmosomal adhesion.

    Conclusions:

    • Desmosomes play a significant role in cell positioning and morphogenesis.
    • Desmosomal cadherins are involved in epidermal differentiation regulation.
    • New insights into desmosomal cadherin involvement in various diseases, including autoimmune, infectious, and genetic disorders.