Related Experiment Video
Updated: Jul 28, 2026

Walk with Me Hybrid Virtual/In-Person Walking for Older Adults with Neurodegenerative Disease
Published on: June 16, 2023
Perindopril improves six minute walking distance in older patients with left ventricular systolic dysfunction: a
S D Hutcheon1, N D Gillespie, I K Crombie
1Section of Ageing & Health, Department of Medicine, University of Dundee, Ninewells Hospital, Dundee, UK.
Objective:
To evaluate the effects of the angiotensin converting enzyme inhibitor perindopril on six minute walking distance and quality of life in very old patients with left ventricular systolic dysfunction.
Design:
Prospective, double blind placebo controlled trial.
Setting:
Medicine for the elderly day hospital.
Patients:
66 patients (average age 81) with left ventricular systolic dysfunction identified by echocardiography.
Interventions:
10 weeks of treatment with titrated doses of perindopril or placebo.
Main Outcome Measures:
Six minute walking distance 10 weeks following treatment, quality of life measurements including the Minnesota living with heart failure questionnaire and the 36 item short form health survey.
Results:
In patients with left ventricular systolic dysfunction, six minute walking distance was significantly increased in the treatment group (37.1 m) compared with the placebo group (-0.3 m, p < 0.001). The medication was well tolerated and there were no significant adverse events.
Conclusions:
Six minute walking distance is improved considerably by treatment with perindopril in older patients with heart failure caused by left ventricular systolic dysfunction.
Related Concept Videos
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Heart Failure V: Medical Management
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Peripheral Artery Disease III: Interprofessional Care

