Cellular longevity: role of apoptosis and replicative senescence
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Updated: Sep 29, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
Ronan T Bree1, Catherine Stenson-Cox, Maura Grealy
1Department of Biochemistry & National Centre for Biomedical Engineering Science, National University of Ireland, Galway, University Road, Galway, Ireland.
Abstract:
Cellular longevity refers to the lifespan of an individual cell. Normal cells have a finite lifespan and typically die by undergoing apoptosis, or enter into a state of irreversible growth arrest, termed replicative senescence, at the end of that lifespan. The lifespan of a cell is a balance between pro-survival/anti-apoptotic and pro-apoptotic death-promoting factors. The role of heat shock proteins, Bcl-2 family members, antioxidant molecules, and telomere length and telomerase activity in the regulation of apoptosis and replicative senescence, will be discussed.
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