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Updated: Jul 29, 2026
Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
Published on: April 11, 2012
Healing of fresh tibial fractures with OP-1. A preliminary report
Pietro Maniscalco1, Dario Gambera, Celeste Bertone
1Dipartimento di Scienze Radiologiche ed Ortopedico-Riabilitative Clinica Ortopedica e Traumatologica, Università degli Studi di Siena. maniscalco@unisi.it
Abstract:
Osteogenic proteins (OP) are elements of a class of natural growth factors called Bone Morphogenetic Proteins (BMP). A specific member of this class is OP-1, a human recombinant protein that has osteogenic properties. The osteoinductive and osteoconductive properties of OP-1, with its specific collagen matrix, promote the generation of new functionally active, biologically and biomechanically mature bone. We carried out a clinical study to verify the potential of this protein in fresh tibial closed fractures, using OP-1 associated with osteosynthesis by means of a monolateral external fixator.
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