[Certain clinico-morphological aspects of microcirculation in partients with chronic nonspecific pneumonia and...

Clinical and morphological studies conducted in chronic non-specific pneumonias and chronic cor pulmonale have demonstrated that these lesions are accompanied by important disorders in the system of microcirculation that manifest themselves in alterations in the rheologic properites of the blood, and in a generalized deterioration of the vascular terminals in the lungs and pleura that are due to the chronic inflammatory process, hypoxia, haemodynamic disorders, and that result in a diffuse intravascular thrombosis. The disturbances in free blood circulation in the microcirculatory system entail significant metabolic shifts that determine the severity of the disease, its progressive course, and lethal result. The increasing intravascular blood clotting in the postcapillary and venular portions of the microcirculatory system, along with a partial reduction of the capillary link, results in an exclusion of a certain portion of the peripheral vascular bed from the circulation process, thus favouring the progress of pulmonary hypertension. Distinct impairment of the coagulation properties of the blood in the microcirculation system in cases of chronic nonspecific pneumonias, stage II-III, and in chronic cor pulmonale require a timely correction thereof, and support the suggestion of the authors as to the inclusion of anticoagulants into the complex of the rapeutic measures for this category of patients.