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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Published on: January 28, 2020

High-sensitivity C-reactive protein is the most effective prognostic measurement of acute coronary events

Laurie G Futterman1, Louis Lemberg

  • 1Department of Medicine, University of Miami School of Medicine, Fla 33101, USA.

American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses
|September 18, 2002
PubMed

Insights

Inflammation drives atherosclerosis development and plaque rupture. High-sensitivity C-reactive protein (hs-CRP) is a validated biochemical marker for predicting coronary events.

Area of Science:

  • Cardiovascular Science
  • Inflammation Biology
  • Biochemical Markers

Background:

  • Arterial atherosclerosis pathogenesis is significantly influenced by inflammation.
  • Inflammatory processes mediate atheroma development, from initial leukocyte recruitment and fatty streaks to unstable plaque formation and rupture.

Observation:

  • Several markers of vascular wall inflammation can predict plaque rupture risk.
  • These markers often lack the specificity of C-reactive protein (CRP).

Findings:

  • Numerous large-scale prospective studies confirm high-sensitivity C-reactive protein (hs-CRP) as a robust biochemical marker.
  • hs-CRP effectively predicts the risk of future first or recurrent coronary events.

Implications:

  • hs-CRP is a valuable tool for cardiovascular risk assessment.
  • A Food and Drug Administration-approved method for hs-CRP measurement is readily available, facilitating clinical application.

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