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Published on: April 16, 2019
Polyploidization and centrosome hyperamplification in inflammatory bronchi
D Lothschütz1, M Jennewein, S Pahl
1Department of Trauma-, Hand- and Reconstructive Surgery, Saarland University, Homburg, Germany.
Objective And Design:
Inflammatory and tumorous bronchi were screened in order to obtain new tumor relevant cytogenetic parameters.
Material Or Subjects:
Bronchial cells of 32 patients were cultivated by standard cell culture procedures.
Methods:
Tetraploidy and aneuploidy was determined by enumeration of chromosome 7 and 8 versus the number of centrosomes. The resulting data were correlated with histopathological data.
Results:
Tetra- and aneuploidy of epithelial cells were detectable in 76% of tumor cell cultures, 75% of high grade inflammatory tissues and 40% of non- and low grade-inflammatory tissues. Additionally, we observed centrosome hyper-amplification and multipolar mitoses not only in the tumor but also in the early stages of inflammation.
Conclusion:
Inflammatory bronchi already show tumor-specific features and may consequently represent the preliminary genetic stage of cancer development in bronchi.
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