Related Experiment Video
Updated: Jul 7, 2026

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
Published on: November 3, 2016
Prognosis for gross motor function in cerebral palsy: creation of motor development curves
Peter L Rosenbaum1, Stephen D Walter, Steven E Hanna
1Department of Pediatrics, School of Rehabilitation Science, CanChild Centre for Childhood Disability Research, McMaster University, Hamilton, Ontario, Canada, L8S 1C7. rosenbau@mcmaster.ca
Insights
This study establishes evidence-based gross motor development curves for children with cerebral palsy (CP) by severity. These curves aid in prognostic counseling and clinical management planning for improved outcomes.
Area of Science:
- Pediatric Rehabilitation
- Neurology
- Developmental Pediatrics
Background:
- Accurate prognostic assessment for cerebral palsy (CP) has been hindered by a lack of validated severity classifications and longitudinal data.
- Difficulty in predicting long-term outcomes impacts clinical management and parental counseling for children with CP.
Purpose of the Study:
- To delineate gross motor development patterns in children with CP, categorized by severity, using longitudinal data.
- To provide a foundation for prognostic counseling and informed clinical management strategies for pediatric CP.
Main Methods:
- A longitudinal cohort study involving 657 children with CP (aged 1-13 years) across 19 rehabilitation centers in Ontario.
- Children were stratified by age and motor function severity, using the 5-level Gross Motor Function Classification System (GMFCS).
- Gross motor function was assessed serially using the Gross Motor Function Measure (GMFM) over a 4-year period (1996-2001).
Main Results:
- Five distinct motor development curves were generated from 2632 GMFM assessments, revealing significant differences in development rates and limits based on CP severity.
- The study identified substantial variation in gross motor development within each severity stratum.
- These curves offer a quantitative basis for understanding developmental trajectories in pediatric CP.
Conclusions:
- Evidence-based prognostication for gross motor progress in children with CP is now feasible, empowering parents and clinicians.
- The developed curves facilitate intervention planning and progress monitoring over time.
- Further research is recommended to characterize the motor function of adolescents with CP.
Context:
Lack of a valid classification of severity of cerebral palsy and the absence of longitudinal data on which to base an opinion have made it difficult to consider prognostic issues accurately.
Objective:
To describe patterns of gross motor development of children with cerebral palsy by severity, using longitudinal observations, as a basis for prognostic counseling with parents and for planning clinical management.
Design:
Longitudinal cohort study of children with cerebral palsy, stratified by age and severity of motor function and observed serially for up to 4 years during the period from 1996 to 2001.
Setting:
Nineteen publicly funded regional children's ambulatory rehabilitation programs in Ontario.
Participants:
A total of 657 children aged 1 to 13 years at study onset, representing the full spectrum of clinical severity of motor impairment in children with cerebral palsy.
Main Outcome Measures:
Severity of cerebral palsy, classified with the 5-level Gross Motor Function Classification System; function, formally assessed with the Gross Motor Function Measure (GMFM).
Results:
Based on a total of 2632 GMFM assessments, 5 distinct motor development curves were created; these describe important and significant differences in the rates and limits of gross motor development among children with cerebral palsy by severity. There is substantial within-stratum variation in gross motor development.
Conclusions:
Evidence-based prognostication about gross motor progress in children with cerebral palsy is now possible, providing parents and clinicians with a means to plan interventions and to judge progress over time. Further work is needed to describe motor function of adolescents with cerebral palsy.
Related Concept Videos
Hierarchy of Motor Control
Neuroplasticity
Role of Cerebellum and Prefrontal Cortex in Memory

