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Quantification of interventricular asynchrony during LBBB and ventricular pacing.
Xander A A M Verbeek1, Kevin Vernooy, Maaike Peschar
1Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, The Netherlands. x.verbeek@fys.unimaas.nl
American Journal of Physiology. Heart and Circulatory Physiology
|September 18, 2002
Summary
This study introduces DeltaT(up) as a reliable measure for quantifying mechanical interventricular asynchrony (IVA). This method accurately assesses ventricular asynchrony and its impact on cardiac function.
Area of Science:
- Cardiology
- Biomedical Engineering
- Physiology
Background:
- Interventricular asynchrony (IVA) impacts cardiac function.
- Quantifying mechanical IVA is crucial for understanding ventricular activation.
- Left bundle branch block (LBBB) is a common cause of significant IVA.
Purpose of the Study:
- To investigate and validate measures for quantifying mechanical interventricular asynchrony (IVA).
- To assess the impact of LBBB and ventricular pacing on IVA.
- To identify the most robust measure for assessing mechanical IVA.
Main Methods:
- Induced left bundle branch block (LBBB) in 12 dogs via radiofrequency ablation.
- Recorded left ventricular (LV) and right ventricular (RV) pressures.
- Validated four IVA measures using computer simulations and experimental data.
Main Results:
- DeltaT(up), the time delay between LV and RV pressure upslope, was identified as the most robust IVA measure.
- LBBB significantly decreased DeltaT(up) and LV dP/dt(max).
- LV apex pacing modulated DeltaT(up), with resynchronization improving LV dP/dt(max) by 15.1%.
Conclusions:
- DeltaT(up) is a reliable and valuable measure for quantifying mechanical IVA.
- This measure provides insight into the nature of asynchronous ventricular activation.
- Understanding mechanical IVA is key for potential therapeutic interventions.