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High Throughput, Real-time, Dual-readout Testing of Intracellular Antimicrobial Activity and Eukaryotic Cell Cytotoxicity
Published on: November 16, 2016
In vitro activity of the new oxazolidinone AZD2563 against Enterococci
G M Eliopoulos1, C B Wennersten, R C Moellering
1Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA. geliopou@caregroup.harvard.edu
Abstract:
The activity of a new oxazolidinone antimicrobial, AZD2563, was assessed against >500 clinical isolates of enterococci representing six species. All isolates, including those resistant to other antibiotic classes, were inhibited by AZD2563 at concentrations =2 micro g/ml, except for four strains resistant to linezolid. In most cases, AZD2563 was twofold more active than linezolid against enterococci.
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