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Simple method for assaying colistin methanesulfonate in plasma and urine using high-performance liquid chromatography
Jian Li1, Robert W Milne, Roger L Nation
1Centre for Pharmaceutical Research, University of South Australia, Adelaide, Australia.
Antimicrobial Agents and Chemotherapy
|September 18, 2002
Abstract:
A simple and sensitive high-performance liquid chromatographic method is described for the determination of colistimethate sodium in plasma and urine. The accuracy and reproducibility was within 10.1 and 11.2% with rat plasma and urine, respectively. Several commonly coadministered antibacterial agents do not interfere with the assay.