Related Experiment Video
Updated: Aug 3, 2026
10:40
Assembly of Nucleosomal Arrays from Recombinant Core Histones and Nucleosome Positioning DNA
Published on: September 11, 2013
Nucleosome sliding: facts and fiction
1Adolf-Butenandt-Institut, Molekularbiologie, Ludwig-Maximilians-Universität, D-80336 München, Germany. pbecker@mol-bio.med.uni-muenchen.de
The EMBO Journal
|September 18, 2002
Summary
Nucleosome sliding, a key outcome of energy-dependent chromatin remodeling, is crucial for dynamic chromatin assembly and nuclear function regulation in eukaryotes.
Area of Science:
- Molecular Biology
- Epigenetics
- Chromatin Dynamics
Background:
- Nucleosome sliding is a common observation in energy-dependent nucleosome remodeling processes studied in vitro.
- Understanding the mechanisms and implications of nucleosome sliding is essential for comprehending chromatin organization.
Purpose of the Study:
- To review the roles of nucleosome sliding in chromatin dynamics.
- To discuss the significance of nucleosome sliding in eukaryotic nuclear functions.
Main Methods:
- Literature review of in vitro studies on energy-dependent nucleosome remodeling.
- Analysis of existing research on chromatin assembly and maintenance.
- Synthesis of findings related to nucleosome sliding and nuclear regulation.
Main Results:
- Nucleosome sliding is a frequent outcome of in vitro nucleosome remodeling.
- Nucleosome sliding plays a role in the dynamic assembly of chromatin.
- This process is implicated in the maintenance of chromatin structure and regulation of nuclear functions.
Conclusions:
- Nucleosome sliding is a fundamental mechanism in chromatin dynamics.
- It contributes to the regulation of gene expression and other nuclear processes.
- Further research into nucleosome sliding will illuminate eukaryotic genome regulation.
Related Concept Videos
02:33The Nucleosome
DNA in a human cell is almost 2m long and it is packed inside a tiny nucleus that is only a few microns in diameter. The level of compaction of DNA inside the nucleus is astonishing. It is organized into several sequentially higher levels of compaction to fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...
DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...
02:10The Nucleosome Core Particle
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
The paradox
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
The paradox
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
02:54Nucleosome Remodeling
Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
02:33The Nucleosome
DNA in a human cell is almost 2m long and it is packed inside a tiny nucleus that is only a few microns in diameter. The level of compaction of DNA inside the nucleus is astonishing. It is organized into several sequentially higher levels of compaction to fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...
DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...
01:19The Nucleosome
Human DNA is almost two meters long. However, it is compressed inside a tiny nucleus measuring only a few microns in diameter. To make this degree of compaction possible, DNA is organized into several sequential levels so that it can fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
In a chromosome, DNA is wound twice around a protein complex called a histone octamer core, which consists of 8 histone proteins. This...
In a chromosome, DNA is wound twice around a protein complex called a histone octamer core, which consists of 8 histone proteins. This...
01:12The Nucleosome Core Particle
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their primary aim is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. On the other hand, they must allow polymerase enzymes to access histone-bound DNA during...
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their primary aim is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. On the other hand, they must allow polymerase enzymes to access histone-bound DNA during...