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Updated: Jun 23, 2026

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
Published on: October 27, 2009
Randomized COMparison of platelet inhibition with abciximab, tiRofiban and eptifibatide during percutaneous coronary
Wayne B Batchelor1, Thaddeus R Tolleson, Yao Huang
1Tallahassee Heart and Vascular Institute, Tallahassee Memorial Healthcare, Tallahassee, Fla 32308, USA. batch002@earthlink.net
Eptifibatide demonstrated the most consistent anti-platelet aggregation effects among glycoprotein IIb/IIIa inhibitors during percutaneous coronary intervention. This study compared abciximab, eptifibatide, and tirofiban in acute coronary syndrome patients.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
- Interventional Cardiology
Background:
- Platelet glycoprotein IIb/IIIa receptor antagonists are crucial in percutaneous coronary intervention (PCI) for acute coronary syndromes (ACS).
- The comparative anti-aggregatory effects of these agents during and after PCI are not well-established.
Purpose of the Study:
- To compare the relative anti-aggregatory effects of abciximab, eptifibatide, and tirofiban.
- To evaluate these effects in patients with ACS undergoing PCI.
Main Methods:
- Randomized trial of 70 ACS patients undergoing PCI.
- Administration of abciximab, eptifibatide, or tirofiban at standard doses.
- Measurement of platelet aggregation (PA) using turbidimetric aggregometry at various time points post-drug initiation.
Main Results:
- Tirofiban showed significantly less PA inhibition early on compared to abciximab and eptifibatide.
- Abciximab exhibited variable anti-aggregatory effects with prolonged infusion.
- Eptifibatide demonstrated the most consistent PA inhibition throughout early and late periods.
Conclusions:
- Glycoprotein IIb/IIIa inhibitors possess distinct pharmacodynamic profiles.
- These differences may influence their clinical efficacy in ACS patients undergoing PCI.
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