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Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation.

G L Lyford1, C-L He, E Soffer

  • 1Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55905, USA.

Gut
|September 18, 2002
PubMed
Summary
This summary is machine-generated.

Interstitial cells of Cajal (ICC) are uniformly distributed in the colon. Slow transit constipation is associated with decreased ICC volume throughout the entire colon.

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Area of Science:

  • Gastroenterology
  • Cell Biology
  • Anatomy

Background:

  • Interstitial cells of Cajal (ICC) are crucial for normal intestinal motility.
  • ICC are present throughout the human colon but are reduced in the sigmoid colon of slow transit constipation patients.

Purpose of the Study:

  • To map the normal distribution of ICC in the human colon.
  • To investigate if ICC are decreased throughout the colon in slow transit constipation.

Main Methods:

  • Human colonic tissues from slow transit constipation patients and controls were analyzed.
  • ICC were identified using c-Kit antibody and confocal microscopy.
  • 3D software reconstructed ICC networks within the colonic muscularis propria and submucosa.

Main Results:

  • ICC form two networks within longitudinal and circular muscle layers.
  • ICC distribution was uniform across the caecum, ascending, transverse, and sigmoid colons.
  • A significant reduction in ICC volume was observed in all colonic regions of slow transit constipation patients.

Conclusions:

  • ICC distribution is relatively uniform throughout the human colon.
  • Idiopathic slow transit constipation is characterized by a pan-colonic decrease in ICC volume.