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Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
Published on: February 28, 2025
Study on the roles of cytokines involved in mycobacterial infection
1Department of Molecular Pathology, Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, 3-1-24, Matsuyama, Kiyose-shi, Tokyo 204-8533, Japan. sugawara@jata.or.jp
Abstract:
The roles of various cytokines in early-phase mycobacterial infection were investigated utilizing murine tuberculosis models. Among them, IFN-gamma and TNF-alpha are very important in protective immunity against mycobacterial infection. This finding is closely associated with human tuberculosis. It is reported that persons with IFN-gamma receptor 1 deficiency and patients with rheumatoid arthritis and Crohn's disease are susceptible to Mycobacterium tuberculosis. It is expected that a novel immunotherapy and a diagnostic method of tuberculosis are developed by clarifying roles of various cytokines immunologically in early-phase mycobacterial infection.
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