Scale-up and endpoint issues of pharmaceutical wet granulation in a V-type low shear granulator

A 3(2) factorial experiment is conducted in a 57 liter low shear granulator to evaluate the influence of changes in binder strength and agitator speed on the response variables of granule size, granule morphology, granule density and torque input. Results are compared to previous work in a 2 liter granulator and scale-up issues between the two granulators are addressed.