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Related Experiment Videos

Keratoconjunctivitis sicca and chronic HCV infection.

D Siagris1, N Pharmakakis, M Christofidou

  • 1Dept. of Internal Medicine, Patras University Hospital, Greece. dsiagris@mland.gr

Infection
|September 19, 2002
PubMed
Summary

Greek patients with chronic hepatitis C virus (HCV) infection show a high prevalence of keratoconjunctivitis sicca (KCS), affecting 36.6%. This dry eye condition is less common in HCV genotype 3a patients and correlates with more advanced liver disease.

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Area of Science:

  • Ophthalmology
  • Hepatology
  • Immunology

Background:

  • Chronic hepatitis C virus (HCV) infection is a global health concern.
  • Ocular manifestations, such as keratoconjunctivitis sicca (KCS), can occur in patients with HCV.
  • Understanding the prevalence and associations of KCS in HCV patients is crucial for comprehensive care.

Purpose of the Study:

  • To determine the prevalence of keratoconjunctivitis sicca (KCS) in Greek patients with chronic hepatitis C virus (HCV) infection.
  • To investigate the association between KCS and HCV genotypes.
  • To explore the relationship between KCS and liver histology in HCV patients.

Main Methods:

  • A cohort of 93 Greek patients with chronic HCV infection and 80 healthy controls were enrolled.

Related Experiment Videos

  • Lacrimal function was assessed using the Schirmer-1 test, break-up time test, and Rose-Bengal staining test.
  • Serum cryoglobulins, rheumatoid factor (RF), and autoantibodies (ANA, anti-SS-A, anti-SS-B) were measured.

    • Main Results:

    • The prevalence of KCS, defined by at least two abnormal lacrimal tests, was 36.6% in HCV patients, significantly higher than in controls (10%).
    • KCS was less prevalent in patients with HCV genotype 3a (16.7%) compared to other genotypes (47.6%), potentially due to younger age.
    • HCV patients with KCS exhibited a higher liver biopsy staging score (4.50) compared to those without KCS (3.06).

    Conclusions:

    • Greek patients with chronic HCV infection have a high prevalence of KCS (36.6%).
    • The low frequency of anti-SS-A and anti-SS-B antibodies suggests distinct pathogenetic mechanisms compared to primary Sjogren's syndrome.
    • KCS in HCV patients is associated with more severe liver disease, highlighting the systemic impact of HCV infection.