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Quinidine does not affect the renal clearance of moxonidine
Stephen D Wise1, Clark Chan, Hans G Schaefer
1Lilly-NUS Centre for Clinical Pharmacology, National University of Singapore, Singapore. sdw@lilly.com
Aims:
To test the hypothesis that the renal clearance of moxonidine decreases when dosed with quinidine.
Methods:
A randomized, two-period study was conducted with six healthy, male subjects orally dosed with either 0.2 mg moxonidine alone or 1 h after 400 mg quinidine sulphate. Pharmacokinetic parameters were calculated using a noncompartmental analysis method.
Results:
When coadministered, quinidine significantly increased moxonidine AUC and t1/2 by 11% and 15%, respectively, and decreased CL/F by 10% compared with the control dosing. CLR and Aeur were not significantly different. Clinically, both treatments were well tolerated.
Conclusions:
Quinidine does not affect the renal clearance of moxonidine. The decrease in apparent total clearance of moxonidine with quinidine coadministration was possibly due to metabolic inhibition, though not likely to be clinically significant.