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Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel
Isabelle Uhoda1, Najat Faska, Caroline Robert
1Unit of Dermocosmetology, Department of Dermatopathology, University Medical Center of Liège, CHU Sart Tilman, B-4000 Liège, Belgium.
Background/Aims:
Beyond subjective assessments, the effect of skin tensors is difficult to assess. The present 2-phase randomized double-blind split face study was designed to compare the effect of a gel containing 3% 2-dimethylaminoethanol (deanol, DMAE) with the same formulation without DMAE.
Methods:
In a first pilot study, sensorial assessments and measures of the skin distension under suction were performed in eight volunteers. In a second study conducted in 30 volunteers, shear wave propagation was measured.
Results:
Large interindividual variations precluded any significant finding in the first study. The DMAE formulation showed, however, a significant effect characterized by increased shear wave velocity in the direction where the mechanical anisotropy of skin showed looseness.
Conclusion:
The DMAE formulation under investigation increased skin firmness.