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[Structure and function of integrons].

Montserrat Sabaté1, Guillem Prats

  • 1Servicio de Microbiología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, España.

Enfermedades Infecciosas Y Microbiologia Clinica
|September 19, 2002
PubMed
Summary
This summary is machine-generated.

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Integrons are genetic elements that capture and express antibiotic resistance genes. Class I integrons, common in clinical bacteria, possess a specific structure facilitating gene cassette integration and spread.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Genetics

Context:

  • Integrons are mobile genetic elements crucial for antibiotic resistance.
  • They facilitate the capture and expression of antibiotic resistance genes.
  • Class I integrons are frequently detected in clinical bacterial isolates.

Purpose:

  • To describe the structure and function of integrons, particularly Class I integrons.
  • To explain the mechanism of gene cassette integration and expression.
  • To highlight the role of integrons in the dissemination of antibiotic resistance.

Summary:

  • Integrons possess an integrase gene (intI) and an attachment site (attI) for gene cassette insertion.
  • Class I integrons feature a conserved 59-CS region, a variable region for gene cassettes, and a fixed 39-CS region (qacEDI and sul1).

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  • While not mobile themselves, integrons are often located on plasmids, enabling their widespread diffusion in bacteria.

    • Impact:

    • Understanding integron structure and function is vital for combating antibiotic resistance.
    • Identifies Class I integrons as key players in the spread of resistance genes.
    • Provides insights into the genetic mechanisms underlying bacterial adaptation to antibiotics.