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Postsurgical pain outcome assessment.

Mark P Jensen1, Connie Chen, Andrew M Brugger

  • 1Department of Rehabilitation Medicine, University of Washington School of Medicine, Box 356490, Seattle, WA 98195-6490, USA. m.jensen@u.washington.edu

Pain
|September 19, 2002
PubMed
Summary
This summary is machine-generated.

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This study compared pain measurement tools in clinical trials. A composite pain score was not consistently better than individual measures like the visual analog scale for detecting treatment effects.

Area of Science:

  • Pain research
  • Clinical trial methodology
  • Analgesic efficacy assessment

Background:

  • Valid pain measures are crucial for clinical trials.
  • Measure sensitivity, detecting changes in pain, is key for treatment evaluation.
  • Factors influencing sensitivity include task complexity, rating scale, and dimensions assessed.

Purpose of the Study:

  • To compare the sensitivity of three outcome measures and a composite score.
  • To evaluate their ability to detect analgesic effects in post-surgical patients.
  • To inform best practices for pain assessment in clinical research.

Main Methods:

  • Compared visual analog scale (VAS), 4-point verbal rating scale (VRS), and 5-point VRS for pain relief.
  • Assessed 123 knee surgery and 124 laparotomy patients receiving morphine, ketorolac, or placebo.

Related Experiment Videos

  • Collected ratings at baseline and up to 24 hours post-surgery.

    • Main Results:

    • The 4-point VRS showed less sensitivity than VAS or pain relief ratings.
    • A composite measure was not consistently superior to individual measures in detecting treatment effects.
    • Pain relief ratings were related to, yet distinct from, pain intensity changes.

    Conclusions:

    • Outcome measure sensitivity varies, impacting clinical trial results.
    • Composite scores do not always offer superior sensitivity for analgesic trials.
    • Pain intensity and relief measures provide complementary information in pain assessment.