The Tissue Distribution of a New Androgen Inducible Cytosol Protein

As a preliminary but important step in the investigation of the function of the new androgen-dependent DNA binding cytosol protein (C(3)P(4)) discovered by using gel retardation assay with a 31 bp fragment of DNA of the promoter of the rat ventral prostatic binding protein (PSBP) C(3) gene as a probe, a general survey was carried out on the tissue distribution of this protein in rat mice, rabbit and monkey of both sexes and also in some human pathological tissues with the following findings: (1) C(3)P(4) is present in all the male sex organs in different amount, but none in female sex organs. (2) C(3)P(4) has been found in the brain of all the species studied. (3) Its occurrence in other tissues are rare and show species variation, but no sex difference. (4) Of the samples collected from 8 different human pathological tissues, stomach cancer, both benign and malignant mammary tumors and three of the benign prostatic hyperplasia tissues revealed certain changes, the potential significance of these findings were discussed.