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Increased aquaporin 1 water channel expression in human brain tumours
S Saadoun1, M C Papadopoulos, D C Davies
1Department of Infectious Diseases, St. George's Hospital Medical School, Cranmer Terrace, Tooting, London SW17 0RE, UK.
British Journal of Cancer
|September 19, 2002
Abstract:
Aquaporin 1 is a water channel protein. There was little aquaporin 1 immunoreactivity in normal brain parenchyma. In astrocytomas, aquaporin 1 was expressed in microvessel endothelia and neoplastic astrocytes. In metastatic carcinomas, aquaporin 1 was present in microvessel endothelia and reactive astrocytes. Aquaporin 1 may participate in the formation of brain tumour oedema.