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Bioactive phenolic derivatives from Acaena splendens methanol extract.

N Backhouse1, C Delporte, R Negrete

  • 1Pharmacognosy Laboratory, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, P.O. Box 233, Santiago 1, Chile.

Phytotherapy Research : PTR
|September 19, 2002
PubMed
Summary

Acaena splendens demonstrated significant fever reduction and anti-inflammatory effects in animal models. Flavonoids isolated from the plant showed potent antipyretic and anti-inflammatory activities, validating traditional medicinal uses.

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Area of Science:

  • Pharmacology
  • Ethnobotany
  • Natural Product Chemistry

Background:

  • Acaena splendens is utilized in Chilean folk medicine for treating fever and inflammation.
  • Scientific validation of its traditional uses is essential for understanding its therapeutic potential.

Purpose of the Study:

  • To investigate the in vivo antipyretic and anti-inflammatory properties of Acaena splendens extracts.
  • To identify the active compounds responsible for these pharmacological effects.

Main Methods:

  • In vivo studies using bacterial pyrogen-induced fever in rabbits and carrageenan-induced paw edema in guinea pigs.
  • Sequential extraction and column chromatography for isolation and purification of active compounds.
  • Bioassay-guided fractionation to identify specific phytochemicals.

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Main Results:

  • The methanol extract (ME-1) exhibited significant antipyretic activity (45.7%).
  • Column fractionation yielded a flavonoid-rich mixture (C4) with potent anti-inflammatory (55.7%) and antipyretic (98.9%) effects at 600 mg/kg.
  • Active compounds identified include (-,-)-epicatechin, tiliroside, 7-O-acetyl-3-O-beta-D-glucosyl-kaempferol, and 7-beta-D-glucosyloxy-5-hydroxy-chromone.

Conclusions:

  • Acaena splendens possesses significant in vivo antipyretic and anti-inflammatory activities.
  • Flavonoids are key contributors to the plant's medicinal properties.
  • The study supports the traditional use of Acaena splendens for fever and inflammation management.