Studies on the cumulation of the toxic effect of indomethacin

The cumulative toxicity of alpha and gamma forms of crystalline indomethacin was studied on Wistar rats treated with these compounds in increasing doses for 24--32 days. The toxic effect of alpha and gamma forms is significantly cumulative. When administration of indomethacin is many times repeated doses 3--4 times lower than those applied once are sufficient to cause death. Indomethacin causes ulcers of small intestinal and cecal mucosa, with perforation. The alpha and gamma crystalline forms of indomethacin did not differ in the degree of cumulation of the toxic effect and intensity of morphological lesions.