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Quantitative angiocardiography--evaluation of left ventricular function in mitral stenosis
Insights
Mitral stenosis impairs left ventricular function, increasing systolic volume and decreasing ejection fraction. The myocardial factor plays a significant role in this dysfunction.
Area of Science:
- Cardiology
- Cardiovascular Physiology
Background:
- Mitral stenosis, a narrowing of the mitral valve, can significantly impact cardiac function.
- Left ventricular (LV) function is crucial for maintaining adequate blood circulation.
- Understanding the specific alterations in LV mechanics is vital for managing mitral stenosis.
Purpose of the Study:
- To investigate left ventricular (LV) function in patients with mitral stenosis.
- To quantify changes in LV volumes, ejection fraction, and stroke volume.
- To explore the relationship between mitral stenosis severity and LV performance.
Main Methods:
- One-plane quantitative angiocardiography was used to assess LV function.
- 59 patients with mitral stenosis and 8 healthy controls were included.
- LV systolic and diastolic volumes, ejection fraction, and stroke volume were measured.
Main Results:
- Patients with mitral stenosis exhibited significantly increased LV systolic volume (74.9 ml vs. 35.2 ml) and decreased ejection fraction (49% vs. 74%) compared to controls.
- Stroke volume was also reduced in patients with mitral stenosis.
- Higher grades of mitral stenosis correlated with reduced ejection fraction and increased systolic volume.
Conclusions:
- Left ventricular function is unequivocally impaired in patients with mitral stenosis.
- The myocardial factor is a considerable contributor to the observed LV dysfunction.
- Quantitative angiocardiography effectively demonstrates these functional impairments.
Abstract:
Investigations of left ventricular function were carried out in 59 patients with mitral stenosis and 8 healthy subjects by means of one-plane quantitative angiocardiography. A statistically significant increase of the left-ventricular systolic volume was observed in patients (x=74.9 +/- 29,8 ml) as compared with the control group (x=35.2 +/- 12,7 ml), the systolic ejection fraction decreased (patients: x=49% +/- 12, controls: x=74% +/-3), similarly as the stroke volume (patients x=74.8 +/- 29.6 ml, controls: x=104 +/- 42 ml). The diastolic volume of the left ventricle was similar in both groups (patients: x=143 +/- 43 ml, controls: x=134 +/- 47.9 ml). A significant decrease of the systolic ejection fraction and an increase of the systolic volume of the ventricle were observed with higher grades of mitral stenosis evaluated according to the classification of the New York Heart Association. A negative correlation was demonstrated between the systolic volume of the left ventricle and the systolic ejection fraction (r=-0.707) and the work of the left ventricle (r=-0.237). On the other hand, a positive correlation was found between the left-ventricular work and the systolic ejection fraction (r=+0.227). The results indicate unequivocally impairment of left ventricular function in mitral stenosis and a considerable role played in it by the myocardial factor.