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In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells
Published on: July 23, 2010
Oestrogen receptor transcripts associated with cervical human papillomavirus infection
M L Shew1, R McGlennen, N Zaidi
1Division of General Pediatrics, University of Minnesota, Minneapolis, USA. mshew@iupui.edu
Sexually Transmitted Infections
|September 20, 2002
Summary
Higher levels of cervical oestrogen receptors transcripts significantly increase the risk of human papillomavirus (HPV) infections in women. This finding highlights a potential role for oestrogen receptors in HPV pathogenesis.
Area of Science:
- Gynecology
- Virology
- Endocrinology
Background:
- Inconsistent findings exist regarding sex steroids as risk factors for human papillomavirus (HPV) infections.
- The specific role of cervical oestrogen receptors in HPV susceptibility remains unclear.
Purpose of the Study:
- To investigate the association between cervical oestrogen receptor transcripts and the presence of cervical HPV infections.
- To determine if oestrogen receptor expression is a risk factor for HPV acquisition or persistence.
Main Methods:
- A study involving 175 women aged 14-44.
- Testing for HPV DNA and oestrogen receptor transcripts in cervical samples.
- Utilizing self-administered questionnaires for sexual and menstrual history data collection.
Main Results:
- 40% of participants tested positive for cervical HPV.
- 99% of HPV-positive women had detectable oestrogen receptor transcripts.
- Cervical HPV infection was strongly associated with oestrogen receptor transcripts (OR=39.8) and number of sexual partners (OR=1.1).
Conclusions:
- Elevated levels of cervical oestrogen receptor transcripts are significantly linked to higher likelihood of HPV infection.
- Oestrogen receptors may play a crucial role in the development of cervical HPV infections.
- Further research into hormonal influences on HPV infection is warranted.
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