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35 years of experimental research in transmyocardial revascularization: what have we learned?
Menno Huikeshoven1, Johan F Beek, Jos A P van der Sloot
1Laser Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. m.huikeshoven@amc.uva.nl
The Annals of Thoracic Surgery
|September 20, 2002
Abstract:
In the past 35 years many experimental studies have been performed to investigate the revascularization potential of transmyocardial revascularization and the possible working mechanisms underlying the observed clinical improvement in angina pectoris after this treatment. In this review of the experimental literature, the various methods that have been used to create transmyocardial channels and the most supported hypotheses on the working mechanism (channel patency, angiogenesis and myocardial denervation) are discussed and evaluated.