Effect of cobra neurotoxin on retention of a brightness discrimination in rats

In view of some recent evidence that blockade of nicotinic acetylcholine receptors might interfere with memory recall, the possibility that intracranial injections of purified corbra neurotoxin, an irreversible nicotinic receptor blocker, would produce long-lasting amnesia was explored with a brightness discrimination habit in rats. The results indicate that even the highest tolerable dose of neurotoxin had no detectable effect on memory recall.