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Massive OxyContin ingestion refractory to naloxone therapy
Aaron B Schneir1, Tyler F Vadeboncoeur, Steven R Offerman
1Division of Medical Toxicology, Department of Emergency Medicine, University of California San Diego Medical Center, 92103-8925, USA. aschneir@ucsd.edu
Abstract:
OxyContin (oxycodone hydrochloride controlled release) is a long-acting preparation of oxycodone that is used as an opioid analgesic to treat chronic pain conditions. We report a patient who ingested a massive quantity of OxyContin and had altered mental status, noncardiogenic pulmonary edema, and hypoventilation that proved refractory to naloxone administration. She required mechanical ventilation for 3 days before recovering completely. The severity and length of poisoning was likely related both to the quantity and formulation of the oxycodone ingested.