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Published on: July 19, 2018

Significance of brain natriuretic peptides in patients on continuous ambulatory peritoneal dialysis

Tatuya Nakatani1, Toshihide Naganuma, Chikayoshi Masuda

  • 1Department of Urology, Osaka City University Medical School, Osaka, Japan.

International Journal of Molecular Medicine
|September 20, 2002
PubMed

Insights

Plasma brain natriuretic peptide (BNP) is elevated in continuous ambulatory peritoneal dialysis (CAPD) patients, correlating with left ventricular hypertrophy and dysfunction. Cardiac load appears lower in CAPD patients compared to hemodialysis (HD) patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Biochemistry

Background:

  • Plasma brain natriuretic peptide (BNP) is a known biomarker for cardiovascular diseases, including congestive heart failure.
  • Elevated BNP levels are reported in hemodialysis (HD) patients, but its role in continuous ambulatory peritoneal dialysis (CAPD) patients is less understood.

Purpose of the Study:

  • To compare plasma BNP concentrations in CAPD patients, HD patients, and healthy volunteers.
  • To investigate the correlation between plasma BNP and echocardiographic parameters in CAPD and HD patients.
  • To assess potential differences in cardiac load between CAPD and HD patients.

Main Methods:

  • Plasma BNP concentrations were measured in 32 CAPD patients, 63 HD patients, and 14 healthy volunteers.
  • Echocardiographic parameters, including left ventricular mass index (LVMI) and left ventricular ejection fraction (LVEF), were analyzed.
  • Statistical comparisons were made between groups, and correlation analyses were performed.

Main Results:

  • Plasma BNP was significantly higher in CAPD patients without cardiovascular disease compared to healthy volunteers (62.1 vs. 9.7 pg/ml).
  • Plasma BNP showed a positive correlation with LVMI and a negative correlation with LVEF in both CAPD and HD patients.
  • Plasma BNP concentration was significantly lower in CAPD patients (114.8 pg/ml) than in HD patients (296.8 pg/ml).

Conclusions:

  • Elevated plasma BNP in CAPD patients suggests an association with left ventricular hypertrophy and systolic dysfunction.
  • Lower plasma BNP levels in CAPD patients compared to HD patients may indicate a reduced cardiac load in CAPD.
  • BNP serves as a valuable biomarker for assessing cardiac status in dialysis patients.

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