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Centrally active phenethylamines.

A T Shulgin, M F Carter

    Psychopharmacology Communications
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    New phenethylamines offer enhanced sensory experiences without hallucinations. These compounds are significantly less potent than their amphetamine counterparts, requiring lower doses for effects.

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    Area of Science:

    • Psychopharmacology
    • Neuroscience
    • Medicinal Chemistry

    Background:

    • The study investigates two-carbon homologs of known psychotomimetic agents.
    • Parent compounds like 4-methyl-2,5-dimethoxyamphetamine (DOM) and 4-bromo-2,5-dimethoxyamphetamine (PBR) are potent hallucinogens.

    Purpose of the Study:

    • To synthesize and characterize two-carbon phenethylamine analogs of DOM and PBR.
    • To evaluate the psychoactive effects, specifically sensory enhancement and duration, in human subjects.

    Main Methods:

    • Synthesis of 4-methyl-2,5-dimethoxyphenethylamine (II) and 4-bromo-2,5-dimethoxyphenethylamine (III).
    • Administration of compounds to human subjects to assess intoxication state, duration, and sensory effects.
    • Comparative potency analysis with parent isopropylamine compounds.

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    Main Results:

    • The synthesized phenethylamines induce intoxication with short duration and heightened sensory perception.
    • Crucially, these compounds do not produce hallucinogenesis in normal subjects.
    • Active oral dosage is 0.1 to 0.2 mg/Kg, indicating approximately one-tenth the potency of their three-carbon analogs.

    Conclusions:

    • Two-carbon phenethylamine analogs of potent psychotomimetics can provide distinct psychoactive effects.
    • These compounds represent a novel class of agents with potential for sensory enhancement without hallucinogenic properties.
    • Further research may explore their therapeutic or research applications.