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Sequence fidelity of a template-directed PNA-ligation reaction
1Max-Planck-Institut für Molekulare Physiologie, Otto-Hahn-Str. 11, D-44227 Dortmund, Germany.
Chemical Communications (Cambridge, England)
|September 21, 2002
Abstract:
The ligation method and an appended duplex-stabilizing dye affect both yield and sequence selectivity of a template-controlled PNA-ligation. The highest selectivity was obtained with a peptide condensation that formed an abasic site.