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Aurones interfere with Leishmania major mitochondrial fumarate reductase
Oliver Kayser1, Ming Chen, Arsalan Kharazmi
1Freie Universität Berlin, Institut für Pharmazie, Pharmazeutische Biotechnologie, Germany. kayser@zedat.fu-berlin.de
Zeitschrift Fur Naturforschung. C, Journal of Biosciences
|September 21, 2002
Abstract:
A series of aurones was analyzed for the ability to inhibit respiratory functions of mitochondria of Leishmania parasites. The aim of this study was to find a rational explanation for the activity of certain aurones and auronols as novel antiprotozoal compounds of plant origin. In a cell-free assay mitochondrial fumarate reductase from L. donovani was inhibited in a concentration-dependent manner. The most active compounds were 4',6-dihydroxyaurone and 6-methoxyaurone which inhibited parasite enzyme activity at 25 nM by over ninety percent.