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Updated: Sep 29, 2026

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
Published on: October 4, 2024
Dynamic stability of signal transduction networks depending on downstream and upstream specificity of protein kinases
Bernd Binder1, Reinhart Heinrich
1Institute of Biology, Math-Nat Dept I, Humboldt University Berlin, Germany. bernd.binder@rz.hu-berlin.de
Abstract:
Mathematical methods are used for explaining the structural design of signal transduction networks, e.g. MAP kinase cascades, which control cell proliferation, differentiation or apoptosis. Taking into account protein kinases and phosphatases the interrelation between the topology of signaling networks and the stability of their ground state are analysed. It is shown that the stability is closely related to the system's dimension and to the number of cycles within the network. Systems with a higher number of kinases and/or cycles tend to be more unstable. In contrast to that increasing phosphatase activity stabilises the ground state.
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