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Related Experiment Videos

Effect of human chorionic gonadotropin on thyroid function in euthyroid men.

J R Sowers, J M Hershman, H E Carlson

    The Journal of Clinical Endocrinology and Metabolism
    |October 1, 1978
    PubMed
    Summary

    Large doses of human chorionic gonadotropin (hCG) showed a weak thyroid stimulator effect in men, causing delayed iodine release but no significant changes in thyroid hormones. No adverse effects were observed, indicating hCG

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    Area of Science:

    • Endocrinology
    • Thyroidology

    Background:

    • Human chorionic gonadotropin (hCG) is a hormone with potential effects on thyroid function.
    • Understanding hCG's impact on the thyroid is crucial for clinical applications and managing hormonal imbalances.

    Purpose of the Study:

    • To investigate the effects of large intravenous doses of hCG on thyroid function in men.
    • To compare the thyroidal iodine release (TIR) response to hCG with that of TSH and TRH.

    Main Methods:

    • Eight healthy men received either 100,000 or 150,000 IU of hCG intravenously.
    • Thyroidal iodine release (TIR) and serum levels of T4, T3, and TSH were monitored post-administration.

    Main Results:

    • All subjects exhibited a delayed and less pronounced TIR response to hCG compared to TSH and TRH.

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  • No significant alterations in serum T4, T3, or TSH levels were observed within 48 hours.
  • No clinical side effects were reported following hCG administration.

    • Conclusions:

    • Human chorionic gonadotropin (hCG) acts as a weak thyroid stimulator in humans.
    • The thyroidal response to hCG is slower and of lower magnitude than responses to endogenous thyroid-stimulating hormones.