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Transfusion of polymerised human haemoglobin in a patient with severe sickle-cell anaemia

Joshua P Raff1, Cassandra E Dobson, Han-Mou Tsai

  • 1Division of Haematology, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY 10467, USA.

Lancet (London, England)
|September 21, 2002
PubMed

Many patients with sickle-cell anaemia have red-cell alloantibodies. We could not obtain compatible blood for a 40-year-old woman with a sickle-cell crisis after a hip operation. We transfused a polymerised human haemoglobin solution, after which the patient's pain was alleviated. This treatment, in combination with erythropoietin, resulted in a rise in our patient's haemoglobin concentration, and her eventual recovery. Increased oxygen delivery to the microcirculation might have contributed to the rapid resolution of pain after the transfusion.

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