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Updated: May 12, 2026

Robotic Ablation of Atrial Fibrillation
Published on: May 29, 2015
Success of serial external electrical cardioversion of persistent atrial fibrillation in maintaining sinus rhythm; a
E Bertaglia1, D D'Este, F Zerbo
1Dipartimento di Cardiologia, Ospedale Civile, Mirano, Venice, Italy.
Insights
An aggressive strategy of repeated electrical cardioversion effectively maintained sinus rhythm in patients with persistent atrial fibrillation for 12 months. This approach also improved left ventricular ejection fraction compared to standard care.
Area of Science:
- Cardiology
- Electrophysiology
Background:
- Persistent atrial fibrillation (AF) poses a significant clinical challenge.
- Maintaining sinus rhythm is crucial for improving patient outcomes.
Purpose of the Study:
- To evaluate the efficacy of a serial external electrical cardioversion strategy.
- To assess its success in maintaining sinus rhythm over 12 months in recurrent persistent AF patients.
Main Methods:
- Prospective, randomized study of 90 patients with persistent AF.
- Group AGG: repeated electrical cardioversion for AF relapse within 1 month.
- Group CTL: no treatment for AF relapse; all patients received antiarrhythmic drugs.
Main Results:
- Sinus rhythm maintained at 12 months: 53% in Group AGG vs. 29% in Group CTL (P<0.03).
- Significant recovery of left ventricular ejection fraction in Group AGG at 6 months (P<0.001).
Conclusions:
- An aggressive policy of repeated electrical cardioversion is effective for maintaining sinus rhythm.
- This strategy is beneficial for patients experiencing early AF recurrence.
Aims:
The aim of this prospective, randomized study was to determine the efficacy of a serial external electrical cardioversion strategy in maintaining sinus rhythm after 12 months in patients with recurrent persistent atrial fibrillation.
Methods And Results:
Ninety patients with persistent atrial fibrillation lasting more than 72 h but less than 1 year were randomized in a one to one fashion to repetition of up to two electrical cardioversions in the event of relapse of atrial fibrillation detected within 1 month of the previous electrical cardioversion (Group AGG), or to non-treatment of atrial fibrillation relapse (Group CTL). ECGs were scheduled at 6 h, 7 days, and 1 month. Clinical examination and ECGs were repeated during the 6-month and 12-month follow-up examinations. Echocardiography was repeated during the 6-month follow-up examination. Clinical and echocardiographic characteristics were similar in the two groups. All patients were treated with antiarrhythmic drugs before electrical cardioversion and throughout follow-up. After 12 months, sinus rhythm was maintained in 53% of Group AGG patients and in 29% of Group CTL patients (P<0.03). After 6 months, left ventricular ejection fraction had recovered significantly only in Group AGG (56.8 +/- 9.0% at enrollment vs 60.4 +/- 9.4% at 6 months,P <0.001).
Conclusion:
These results demonstrate that an aggressive policy towards persistent atrial fibrillation by means of repetition of electrical cardioversion after early atrial fibrillation recurrence is useful in maintaining sinus rhythm after 12 months.
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