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[Experimental study on antiendotoxin effect of extracts from Artemisia annua L]
Abstract
Objective:
To explore the antiendotoxin effect of extracts from Artemisia annua (AA) and qinghaosu (QHS).
Method:
LPO and SOD in chondriosome, ACP in lysosomes, tumor nicrosis factor-alpha(TNF-alpha) and endotoxin in plasma, and P450 concentration in hepatic microsome of rats were determined. Mortality of endotoxemic mice and histomorphology were observed.
Result:
LPO, ACP, endotoxin, TNF-alpha and P450 content were decreased with AA and QHS. SOD activity was increased with AA and QHS. At the same time, mortality was decreased. Histomorphology of lysosomes and chondriosome of rats were protected from endotoxin.
Conclusion:
AA and QHS possess an antiendotoxin effect.