Related Experiment Video
Updated: Jul 16, 2026

A Functional Assay for Gap Junctional Examination; Electroporation of Adherent Cells on Indium-Tin Oxide
Published on: October 18, 2014
Structure and activity of insect cytokine GBP which stimulates the EGF receptor
Tomoyasu Aizawa1, Yoichi Hayakawa, Katsutoshi Nitta
1Bio-oriented Technology Research Advancement Institution, Saitama, Japan.
Abstract:
Growth-blocking peptide (GBP) is an insect cytokine that possesses diverse biological activities such as larval growth regulation, cell proliferation, and stimulation of immune cells. GBP is a 25-amino acid peptide with one disulfide bond. It has been revealed that the tertiary structure of GBP consists of an N- and C-terminal disordered region and a well-structured core. Although there is only a slight similarity between the primary structures of GBP and EGF and the molecular weight of GBP is about half that of EGF, GBP directly binds and activates the EGF receptor of human keratinocyte cells. Furthermore, the tertiary structure of the well-defined region of GBP is similar to that of the C-terminal domain of EGF. This review will focus on the tertiary structure of GBP and its activities, as compared with those of EGF.
More Related Videos
Related Concept Videos
Assembly of Signaling Complexes
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Amplifying Signals via Enzymatic Cascade
TGF - β Signaling Pathway
Activation and Inactivation of G Proteins
GPCRs Regulate Adenylyl Cylase Activity
Two...
IP3/DAG Signaling Pathway

