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Do S100beta protein level increases due to inflammation during cardiopulmonary bypass occur without any neurological

Mehmet Ali Ozatik1, Onurcan Tarcan, Arzum Kale

  • 1Cardiovascular Surgery Clinic, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey.

Perfusion
|September 24, 2002
PubMed

Insights

Pulsatile cardiopulmonary bypass (CPB) is associated with lower S100beta protein levels compared to nonpulsatile CPB. This suggests pulsatile flow may mitigate the inflammatory response during cardiac surgery.

Area of Science:

  • Cardiovascular Surgery
  • Biomarkers
  • Inflammation

Background:

  • S100beta protein is a marker of cellular damage.
  • Cardiopulmonary bypass (CPB) duration and aortic crossclamp times influence S100beta levels.
  • Pulsatile and nonpulsatile CPB may differentially affect S100beta release.

Purpose of the Study:

  • To investigate the time course of S100beta protein release during and after pulsatile versus nonpulsatile CPB.
  • To compare inflammatory markers between pulsatile and nonpulsatile CPB.

Main Methods:

  • Prospective study of 40 patients undergoing open-heart surgery.
  • 20 patients received pulsatile flow CPB, 20 received nonpulsatile flow CPB.
  • S100beta protein, C3a, interleukins, and white blood cells were measured at multiple time points.

Main Results:

  • Pulsatile CPB group showed significantly lower S100beta and C3a levels post-unclamping.
  • Pulsatile CPB group had lower C3a and neutrophil counts at 1-hour postoperatively.
  • All patients survived and were discharged without neurological deficits.

Conclusions:

  • Serum S100beta protein levels increase during CPB, with a higher increase in the nonpulsatile group.
  • Elevated S100beta is linked to increased inflammatory mediators and systemic inflammatory response.
  • Pulsatile CPB may be associated with a reduced inflammatory response.
Abstract

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