Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Citalopram-associated SIADH.

Teresa S Barclay1, Audrey J Lee

  • 1Pharmacy Department, Veterans Affairs Medical Center, San Francisco, CA 94121, USA. teresa.barclay@med.va.gov

The Annals of Pharmacotherapy
|September 24, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dopamine Dysregulation Syndrome in Parkinson's Disease.

The Senior care pharmacist·2025
Same author

Impacts of a COVID-19 Educational Video: Evaluation of the Influence of Race, Gender, Political Affiliation, Study Major, and Age on Vaccine Acceptance among University Students.

European journal of investigation in health, psychology and education·2023
Same author

Assessing Preceptor and Student Perceptions of Remote Advanced Pharmacy Practice Experience Learning during the COVID-19 Pandemic.

Pharmacy (Basel, Switzerland)·2022
Same author

Adapting pharmacy experiential education during COVID-19: Innovating remote preceptor resources, tools, and patient care delivery beyond virtual meetings.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists·2021
Same author

Amantadine Associated Myoclonus: Case Report and Review of the Literature.

Journal of pharmacy practice·2021
Same author

High-Intensity Atorvastatin-Induced Rhabdomyolysis in an Elderly Patient With NSTEMI: A Case Report and Review of the Literature.

Journal of pharmacy practice·2016

Citalopram use in elderly males can cause syndrome of inappropriate antidiuretic hormone secretion (SIADH), leading to hyponatremia. Monitor older patients for SIADH symptoms, particularly during dose changes and early treatment.

Area of Science:

  • Endocrinology
  • Geriatric Medicine
  • Clinical Pharmacology

Background:

  • Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a potential adverse effect of selective serotonin reuptake inhibitors (SSRIs).
  • Citalopram, an SSRI, has been rarely associated with SIADH and subsequent hyponatremia.

Observation:

  • An 87-year-old male developed malaise, confusion, and falls after a citalopram dose increase.
  • Laboratory findings confirmed hyponatremia, hypoosmolality, and urine hyperosmolality, indicative of SIADH.
  • Discontinuation of citalopram and fluid restriction led to serum sodium normalization and symptom resolution.

Findings:

  • This case represents the seventh report of citalopram-induced hyponatremia and the second in a male patient.
  • Onset of SIADH or hyponatremia ranged from 6 to 20 days after initiating or increasing citalopram.

Related Experiment Videos

  • Risk factors include advanced age, female gender, concurrent SIADH-inducing medications, and potentially higher citalopram doses.

    • Implications:

    • Elderly patients on citalopram require vigilant monitoring for SIADH symptoms.
    • Monitoring is crucial during the initial weeks of therapy, during dose escalation, and in patients with risk factors.
    • Early recognition and management of citalopram-induced SIADH can prevent serious complications.