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Related Experiment Videos

Antidepressant-induced sexual dysfunction.

Razmic S Gregorian1, Katharine A Golden, Asena Bahce

  • 1The Lewin Group, Falls Church, VA 22042, USA.

The Annals of Pharmacotherapy
|September 24, 2002
PubMed
Summary
This summary is machine-generated.

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Antidepressant-induced sexual dysfunction is common, especially with SSRIs, affecting 30-60% of patients. Bupropion, nefazodone, and mirtazapine have lower rates, suggesting treatment strategy adjustments.

Area of Science:

  • Pharmacology and Therapeutics
  • Psychiatry and Mental Health

Background:

  • Sexual dysfunction is a recognized adverse effect of many antidepressant medications.
  • The prevalence and impact of antidepressant-induced sexual dysfunction (AISD) require careful consideration in clinical practice and health policy.

Purpose of the Study:

  • To review existing evidence on sexual dysfunction caused by antidepressants.
  • To inform treatment strategies and health plan coverage policies for antidepressant medications.

Main Methods:

  • Systematic literature search of MEDLINE and HealthSTAR (1986-2000) for English-language studies.
  • Included randomized controlled trials (RCTs), open-label studies, case series; excluded case reports and letters.
  • Data extraction and synthesis, augmented by a panel survey.

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Main Results:

  • AISD is a common adverse effect, with rates potentially higher in clinical practice than reported.
  • Selective serotonin-reuptake inhibitors (SSRIs) are most frequently associated with AISD (30-60% of patients).
  • Bupropion, nefazodone (<10%), and mirtazapine demonstrate significantly lower rates of sexual dysfunction.

Conclusions:

  • Physicians must actively monitor for AISD to ensure treatment compliance and success.
  • AISD impacts patient well-being and may necessitate additional healthcare resources, relevant for managed care.