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Published on: December 9, 2015

Aspirin resistance.

Patricia A Howard1

  • 1Department of Pharmacy, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160-7231, USA. phoward@kumc.edu

The Annals of Pharmacotherapy
|September 24, 2002
PubMed
Summary
This summary is machine-generated.

Aspirin resistance in vascular disease patients is a reported issue, but its significance remains unclear due to varied definitions and detection methods. Further research is needed to identify at-risk patients for alternative therapies.

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Area of Science:

  • Cardiovascular Medicine
  • Thrombosis Research
  • Pharmacology

Background:

  • Aspirin is a widely used antithrombotic agent for vascular disease.
  • Variable patient responses to aspirin have been observed, leading to the concept of aspirin resistance.
  • The clinical significance of aspirin resistance in vascular disease is not well-established.

Purpose of the Study:

  • To review existing literature on aspirin resistance in patients with vascular disease.
  • To explore the reported prevalence, mechanisms, and clinical implications of aspirin resistance.

Main Methods:

  • A comprehensive literature search was conducted using MEDLINE (1966-February 2002).
  • Key search terms included "aspirin," "resistance," "failure," "tolerance," and "nonresponder."
  • English-language studies and relevant references were identified and reviewed.

Main Results:

  • Aspirin resistance has been documented in patients with cardiovascular, cerebrovascular, and peripheral vascular disease.
  • Inconsistent definitions and detection methods hinder the assessment of aspirin resistance's true impact.
  • Proposed mechanisms include increased platelet reactivity, genetic factors, and alternative thromboxane synthesis pathways.
  • Current studies lack consistent evidence linking aspirin's effects, dosage, and clinical outcomes.

Conclusions:

  • While aspirin is effective for many, some patients exhibit variable platelet aggregation responses and may experience thromboembolic events.
  • A lack of uniform definition and diagnostic criteria for aspirin resistance prevents definitive recommendations.
  • Identifying patients at risk for aspirin resistance is crucial for considering alternative or combination antiplatelet therapies.