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Indapamide-induced pemphigus foliaceus.

D Bayramgürler¹, C Erçin, R Apaydin

¹Department of Dermatology, Kocaeli University School of Medicine, Izmit, Turkey. efe99@usa.net

The Journal of Dermatological Treatment

|September 24, 2002

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This case report details a patient who likely developed pemphigus foliaceus due to the medication indapamide. This is the first documented instance of indapamide-induced pemphigus, highlighting potential drug-induced dermatoses.

Area of Science:

Dermatology
Immunology
Pharmacology

Background:

Drug-induced pemphigus is a recognized phenomenon, with various medications linked to its onset.
Pemphigus foliaceus is an autoimmune blistering disease affecting the superficial layers of the epidermis.

Observation:

A patient presented with clinical and histological features consistent with pemphigus foliaceus.
Diagnostic evaluation included direct immunofluorescence testing, which supported the diagnosis.

Findings:

The patient's condition is strongly suspected to be induced by indapamide, a diuretic medication.
This represents the first reported case of pemphigus foliaceus potentially caused by indapamide.

Implications:

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This case expands the list of potential causative agents for drug-induced pemphigus.

Clinicians should consider indapamide as a possible trigger in patients presenting with pemphigus foliaceus.

Further research may be warranted to explore the mechanism of indapamide-induced autoimmunity.