Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A model to simulate day-to-day variations in rectum shape.

Mischa S Hoogeman1, Marcel van Herk, Di Yan

  • 1Department of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

International Journal of Radiation Oncology, Biology, Physics
|September 24, 2002
PubMed
Summary

A new model predicts rectum shapes during prostate cancer radiotherapy, improving dose accuracy. This simulation tool enhances analysis of rectal dose and gastrointestinal toxicity risk.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Different Commercial Formulations of Tannic Acid Added at an Equal Inclusion Rate on Intestinal Health and Microbial Flora in Yellow-Feathered Broilers.

Animals : an open access journal from MDPI·2026
Same author

SBRT embedded in low-dose RT plus αPD-1 (immuno-EclipseRT, iERT) elicits CD8<sup>+</sup> T cell immunity against bulky tumors via an IFN-I/NK/DC axis.

Nature communications·2026
Same author

Tailoring radiotherapy in cT1-2N1 breast cancer to nodal response on primary chemotherapy (RAPCHEM: BOOG 2010-03): 10-year follow-up results of a Dutch, prospective, registry study.

The Lancet. Oncology·2026
Same author

A homozygous splicing mutation in CCDC39 caused multiple morphological abnormalities of the flagella in an infertile man with primary ciliary dyskinesia.

Asian journal of andrology·2026
Same author

Recruitment of the outer-membrane lipoprotein DolP to the division site via anionic phospholipid-mediated diffusion-state switching.

Molecular biology of the cell·2026
Same author

Development of H<sub>2</sub>O<sub>2</sub>-Driven Peroxygenase-Type P450BM3 for Efficient Substrate Removal of Lignin-Derived Phenolics.

Journal of agricultural and food chemistry·2026

Area of Science:

  • Radiation Oncology
  • Medical Physics
  • Computational Biology

Background:

  • Accurate rectum modeling is crucial for effective prostate cancer radiotherapy.
  • Variations in rectal shape during treatment can impact radiation dose delivery.
  • Existing methods may not fully capture intra-fractional rectal changes.

Purpose of the Study:

  • To develop a predictive model for rectum configurations during prostate cancer radiotherapy.
  • To improve the accuracy of rectal dose estimation using planning CT scans and patient data.

Main Methods:

  • A stochastic shape description model simulating rectum motion slice-by-slice.
  • Utilized Monte Carlo techniques with probability distributions derived from repeat CT scans of reference patients.
  • Validated the model by comparing dose-wall histograms (DWHs) and equivalent uniform dose (EUD).

Related Experiment Videos

Main Results:

  • Simulated rectum configurations provided a more accurate estimate of rectal wall dose compared to planning CT alone.
  • Reduced the range of equivalent uniform dose (EUD) prediction errors from -1.1 Gy to 2.1 Gy to -0.4 Gy to 0.6 Gy.
  • The model estimates variations in DWHs, aiding in gastrointestinal toxicity analysis.

Conclusions:

  • A novel model effectively simulates rectum shapes for radiotherapy planning.
  • This model enhances the analysis of rectal dose and potential toxicity during prostate cancer treatment.
  • The simulation tool complements planning CT data for improved treatment assessment.